Behandlung der akut intermittierenden Porphyrie mit einem neuen, an Albumin gebundenen lyophilisierten Hämatin

Autor:	H. Ippen, Th. Fuchs
Rok vydání:	2008
Předmět:	medicine.medical_specialty business.industry Tetraparesis General Medicine Urine medicine.disease Thrombophlebitis Gastroenterology chemistry.chemical_compound chemistry Internal medicine Porphobilinogen polycyclic compounds Medicine business Acute intermittent porphyria
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 112:1302-1305
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1068240
Popis:	Hematin (iron-III-protoporphyrin 9) has been used for several years in the treatment of acute attacks of inducible porphyrias. Three patients were treated with a new, albumin-bound lyophilized hematin preparation (manufactured by Behringwerke). In all patients it achieved a reduction in the urine of the porphyrin precursors porphobilinogen and 5-aminolevulin acid. In two patients the clinical symptoms were clearly improved, while a third patient died with tetraparesis. Hematin administration proved superior to the preceding glucose treatment. No abnormality of clotting or thrombophlebitis was detectable after hematin infusion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a70862f0d87c201b46e0ed38e1a23171 https://doi.org/10.1055/s-2008-1068240 Zobrazit plný text záznamu