Pre Ischemic Administration of L-NAME Reinstates Behavior, Improves Motor Activity and Alleviates Excitotoxicity in Middle Cerebral Artery Occlusion/Reperfusion Rats

Autor:	R. Barathidasan, C. Saravana Babu, Periyathambi Kalaivani, B. Pramila
Rok vydání:	2015
Předmět:	Elevated plus maze Multidisciplinary medicine.drug_class business.industry Ischemia Excitotoxicity H&E stain medicine.disease medicine.disease_cause Anxiolytic Anesthesia medicine.artery Middle cerebral artery medicine Middle cerebral artery occlusion Motor activity business
Zdroj:	Indian Journal of Science and Technology. 8:692
ISSN:	0974-5645 0974-6846
DOI:	10.17485/ijst/2015/v8is7/63163
Popis:	Objectives: To study the effect of NG nitro L Arginine Methyl Ester (L-NAME) on anxiety, cognition, motor activity and neuronal damage when administered pre, during and post ischemically in rats. Methods: L-NAME was administered 30 minutes before inducing ischemia (Preischemic), 1 hour after ischemia (During ischemic) and 3 hours after reperfusion (Post ischemic). After 72 hours of reperfusion, animals were assessed for anxiety using elevated plus maze test, cognition using Y-maze test and motor activity using beam walk and rota rod test. Rats were euthanized using carbon di oxide and the brains were collected. Neuronal damage was studied in the brain sections using hematoxylin and eosin stained brain sections. Findings: Pre ischemic administration of L-NAME has increased the time spent (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a6e6b300290ba51626e0e31cd081f895 https://doi.org/10.17485/ijst/2015/v8is7/63163 Zobrazit plný text záznamu