The effects of afterload and stimulation delay on the slow force response in the heterogeneous myocardium
| Autor: | Alexander Kursanov, Yu. L. Protsenko, R. V. Lisin, A. A. Balakin, Olga Solovyova, S. Yu. Khamzin |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030103 biophysics medicine.medical_specialty Contraction (grammar) Chemistry Biophysics Theoretical models Stimulation Isometric exercise Calcium in biology Contractility 03 medical and health sciences Afterload Duplex (building) Internal medicine cardiovascular system medicine Cardiology |
| Zdroj: | Biophysics. 61:759-764 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350916050171 |
| Popis: | The results of numerical simulations and physiological experiments that assessed the dependence of the intramyocardial slow force response under an afterload in the heterogeneous myocardium are described. Muscle duplexes of our design were used as the simplest experimental and theoretical models of the heterogeneous myocardium. It is shown that the degree of the slow force response increases with an afterload and the time of the stimulation delay between the elements of the duplex. This effect is explainable by an increase in the time of the mechanical interaction between the duplex elements in the isometric phase of contraction. This leads to changes in individual contractility, the configuration of the action potential, and the kinetic characteristics of intracellular calcium in cardiomyocytes of interacting muscles. |
| Databáze: | OpenAIRE |
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