Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response
| Autor: | Ralph S. DaCosta, Angela Ip, Claudia R. Gordijo, Azhar Z. Abbasi, Preethy Prasad, Xiao Yu Wu, Andrew M. Rauth, Azusa Maeda |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Tumor microenvironment biology General Engineering Serum albumin General Physics and Astronomy In vitro 3. Good health Vascular endothelial growth factor chemistry.chemical_compound chemistry Biochemistry Tumor progression Cancer cell biology.protein medicine Cancer research General Materials Science medicine.symptom Acidosis |
| Zdroj: | ACS Nano. 8:3202-3212 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/nn405773r |
| Popis: | Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive oxygen species (ROS), such as H2O2, are characteristic abnormalities of the tumor microenvironment (TME). These abnormalities promote tumor aggressiveness, metastasis, and resistance to therapies. To date, there is no treatment available for comprehensive modulation of the TME. Approaches so far have been limited to regulating hypoxia, acidosis, or ROS individually, without accounting for their interdependent effects on tumor progression and response to treatments. Hence we have engineered multifunctional and colloidally stable bioinorganic nanoparticles composed of polyelectrolyte–albumin complex and MnO2 nanoparticles (A-MnO2 NPs) and utilized the reactivity of MnO2 toward peroxides for regulation of the TME with simultaneous oxygen generation and pH increase. In vitro studies showed that these NPs can generate oxygen by reacting with H2O2 produced by cancer cells under hypoxic conditions. A-MnO2 NPs simultaneously... |
| Databáze: | OpenAIRE |
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