Enantioselective Synthesis of Axially Chiral 1-Arylisoquinolines by Iridium(I)-Catalyzed Hydroarylation of Alkynes
| Autor: | Shu-Li You, Qing Gu, Qiansujia Zhou, Si-Yong Yin, Dong-Song Zheng, Wen-Wen Zhang, Su-Zhen Zhang |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Synlett. |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/a-2021-9514 |
| Popis: | Ir(I)-catalyzed atroposelective hydroarylation of alkynes with 1-arylisoquinolines through C–H functionalization was realized. In the presence of 5 mol% of [Ir(cod)Cl]2 and 10 mol% of QUINOX-P, a wide range of axially chiral alkenylated biaryls were obtained in up to 98% yield and 97% ee. Notably, only one equivalent of the alkyne was required to guarantee a high efficiency of this C–H functionalization process. This reaction exhibits excellent functional-group tolerance under mild conditions. |
| Databáze: | OpenAIRE |
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