ChemInform Abstract: Triflic Acid-Mediated Rearrangements of 3-Methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: Synthesis of Methoxytropolones and Furans

Autor:	Christine Meck, Ryan P. Murelli, Noushad Mohd, Yvonne D. Williams
Rok vydání:	2014
Předmět:	Dimethyl acetylenedicarboxylate chemistry.chemical_compound chemistry Biological activity General Medicine Medicinal chemistry Triflic acid
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201419034
Popis:	Methoxytropolones are useful scaffolds for therapeutic development because of their known biological activity and established value in the synthesis of α-hydroxytropolones. Upon treatment with triflic acid, a series of 3-methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones rearrange rapidly and cleanly to form methoxytropolones. Interestingly, bicycles that are derived from dimethyl acetylenedicarboxylate (R2 = R3 = CO2Me) instead form furans as the major product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a6cdfe08e2e8fb9010a919c89c67e310 https://doi.org/10.1002/chin.201419034 Zobrazit plný text záznamu Plný text