Polycyclic fused amidines. Part III. An unexpected mode of cyclisation of 2-phenacylisoquinolinium bromide

Autor:	John E. Airey, Andrew S. Kende, David P. Nowotnik, Robert T. Parfitt, Ronald F. Cookson
Rok vydání:	1976
Předmět:	Part iii chemistry.chemical_compound Acetic acid chemistry Bromide Quinoline Organic chemistry Isoquinoline Ring (chemistry) Ammonium acetate Medicinal chemistry
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :201
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19760000201
Popis:	Treatment of 2-phenacylisoquinolinium bromide with ammonium acetate in acetic acid gave 5,10-dihydro-2-phenylimidazo[1,2-b]isoquinoline (4) by cyclisation at the 3-position of the isoquinoline ring. The mechanism of this reaction is discussed. On similar treatment 1-phenacylquinolinium bromide gave 4,5-dihydro-2-phenyl-imidazo[1,2-a]quinoline (8).
Databáze:	OpenAIRE
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