ChemInform Abstract: Asymmetric Construction of the Azaspiro[5.6]dodec-9-ene System in Marine Natural Toxins

Autor:	Mariko Horie, Jun Ishihara, Akio Murai, Yoshikatsu Shimada, Shingo Tojo
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Diene Imine Caprolactam Organic chemistry Moiety General Medicine Ene reaction
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200230254
Popis:	The asymmetric formation of azaspiro[5.6]dodec-9-ene system is described. The Diels-Alder reactions of an α-methylene caprolactam and diene in the presence of a Cu(II) and (S,S)-tBu-BOX complex afford the desired spirocyclic compounds with good exo-selectivity as well as excellent enantioselectivity. These exoadducts would be applicable to the synthesis of marine natural toxins including the corresponding cyclic imine moiety.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a6c4c596373dc3d871cc1d5363ea4cab https://doi.org/10.1002/chin.200230254 Zobrazit plný text záznamu Plný text