Short Communication:Association between Tipranavir Plasma Levels and Virological Response in HIV-Infected Patients
| Autor: | Beatriz Sanz, Inmaculada Jiménez-Nácher, Gema González-Pardo, Sonia Rodriguez-Novoa, Carmen de Mendoza, Pilar Garcia Gascó, Judit Morello, Vincent Soriano, Francisco J. Blanco |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
medicine.medical_specialty biology medicine.diagnostic_test Immunology Plasma levels medicine.disease biology.organism_classification Cmin Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Therapeutic drug monitoring Virology Internal medicine Immunopathology medicine Viral disease Sida Tipranavir medicine.drug |
| Zdroj: | AIDS Research and Human Retroviruses. 24:389-391 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | The impact of tipranavir plasma levels (TPV Cmin) on virological response was examined in 36 antiretroviral-experienced HIV-infected individuals. Although TPV Cmin did not predict outcome in patients with less than five or more than eight baseline TPV-associated resistance mutations, TPV Cmin values were greater in responders than in nonresponders with five to seven baseline TPV-associated resistance mutations (38.8 vs. 13.8 g/ml, p = 0.017). Thus, therapeutic drug monitoring might be helpful in ensuring a viral response in this subset of patients. |
| Databáze: | OpenAIRE |
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