Synthesis of 3-Noradamantamine
| Autor: | Peter Kovacic, Mikolaj Jawdosiuk |
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| Rok vydání: | 1983 |
| Předmět: | |
| Zdroj: | Synthetic Communications. 13:53-62 |
| ISSN: | 1532-2432 0039-7911 |
| DOI: | 10.1080/00397918308061958 |
| Popis: | Bridgehead primary amines in the bicyclic and tricyclic category have served as important intermediates in organic synthesis. When transformed into azo compounds, they can be used as a source of bridgehead free radicals.1 These amines also serve as precursors of azides which, when subjected to photolysis, lead to bridge-head imines (limits of Bredt's rule).2 The N,N-dichloro derivatives undergo skeleton rearrangements in the presence of strong Lewis acids resulting in ring expansion with incorporation of nitrogen.3 Bicyclic and tricyclic bridgehead amines and their derivatives exhibit a wide spectrum of pharmacodynamical properties.4 |
| Databáze: | OpenAIRE |
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