Rifaximin as Short-Term 'Bridge Therapy' in Mild-Moderate Left Sided Colitis Resistant to 5 ASA

Autor: M. Apuzzo, Tammaro G, M. E. Bazuro, G. Pippa, M. Ferrara
Rok vydání: 2004
Předmět:
Zdroj: Gastrointestinal Endoscopy. 59:P272
ISSN: 0016-5107
DOI: 10.1016/s0016-5107(04)01205-2
Popis: *W1625 WITHDRAWN Rifaximin as Short-Term ‘‘Bridge Therapy’’ in Mild-Moderate Left Sided Colitis Resistant to 5 ASA. Gianfranco Tammaro, M. Apuzzo, M. E. Bazuro, M. Ferrara, G. Pippa Background And Aims: Rifaximin, a well tolerated,non absorbable,wide spectrum antibiotic,has a topical action without systemic effects. Aim of the studywas to evaluate the efficacy of rifaximin, in a populationof patients withmild to moderate left sided ulcerative colitis resistant to topic and oral 5ASA. Material And Methods: We enrolled 18 outpatients (10 F,8M, Mean age 45,4 y., range 2271) from June 2001 through July 2003 with first attack or relapsing ulcerative colitis, ,without clinical and endoscopic signs of severe colitis, who failed to respond to a 2 weeks course of 5ASA 4.8 gr orally and 4 gr topically. The clinical activity of disease was defined in accordance with Truelove and Witts criteria. Colonoscopy was performed and endoscopic activity was defined in accordance with Baron criteria. All pts complained of >= 6 bowel movements with blood. Routine haematological and biochemical measurements were made at the beginning and after two weeks rifaximin therapy. Three pts had rectal involvement, 10 proctosigmoiditis, 5 left sided colitis. These pts instead of shifting to oral steroid treatment, as a rule, were offered a 2 weeks course of rifaximin 400 mg thrice daily plus 5ASA therapy. At end point pts were considered to be improved if they had =/< 3 bowel movements per day without blood. Pts improved were mantained with ongoing 5 ASA therapy and followed for amedian of 13.7 months ( range4-27 ) to evaluate relapse rate. Colonoscopy was performed after 2 months and during flare-up. Results: Compliance was excellent and there was non significant changes in haematological and biochemical parameters. Overall 9 pts (50%) showed a positive response to treatment with
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