Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups
| Autor: | Gholam H. Hakimelahi, Jih Ru Hwu, Krishna S. Ethiraj |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Bicyclic molecule Chemistry Mesylate Stereochemistry Heteroatom Biological activity General Medicine biochemical phenomena metabolism and nutrition chemistry.chemical_compound Drug Discovery β lactams polycyclic compounds Organic chemistry Antibacterial activity Trifluoromethanesulfonate |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 3:305-313 |
| ISSN: | 1389-5575 |
| DOI: | 10.2174/1389557033488132 |
| Popis: | This Review contains our recent studies on evaluation of biological activities associated with monocyclic β-lactams and bicyclic β-lactam antibiotics containing various heteroatoms. A series of bicyclic β-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These β-lactams exhibited enhanced antibacterial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|