In Vivo Confocal Microscopy for Studying Corneal Diseases and Conditions Associated with Corneal Nerve Damage
| Autor: | Jukka A O Moilanen, Ilpo S. J. Tuominen, Tuuli U Valle, Timo Tervo, Maria E. Rosenberg, Minna H Vesaluoma |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Basement membrane
medicine.medical_specialty genetic structures business.industry Confocal Reflex arc Corneal Diseases Dystrophy Meibomian gland Lacrimal gland eye diseases 3. Good health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Cornea Ophthalmology 030221 ophthalmology & optometry medicine sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781461352082 |
| DOI: | 10.1007/978-1-4615-0717-8_92 |
| Popis: | Corneal sensory nerves are involved not only in corneal healing1–5 but they also participate in the reflex arc regulating tear fluid flow.6–8 Recent studies have also revealed that both stromal keratocytes and basal epithelial cells are innervated,9 an observation that further underlines the potential importance of neural input in corneal healing. In vivo confocal microscopy (CM) has proven to be a relatively reliable method for studying corneal nerves in clinical patient materials.10–13 The recovery of the normal morphology of the subbasal nerve bundles correlates with the restoration of corneal sensitivity.11 Unfortunately the Cochet-Bonnet esthesiometer seems to be relatively insensitive in detecting sensory alterations when compared with a non-contact gas esthesiometer.12 Nonhealing corneal ulcers are frequently associated with impaired corneal sensitivity and ocular surface pathology.14,15 Consequently, clinical tools that enable the direct evaluation of corneal innervation are needed. The current chapter is a review on our confocal microscopical findings on some post-surgical conditions such as PRK10 and LASIK,11,13,16,17 as well as some corneal diseases: familial amyloidosis type II/Meretoja disease,18 autosomal dominant cornea plana19, basement membrane dystrophy/recurrent erosion syndrome,20,21 diabetic neuropathy,20,22 herpes keratitis20 and Sjogren’s syndrome. |
| Databáze: | OpenAIRE |
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