Molecular biology of meniscus pathology: Lessons learned from translational studies and mouse models
| Autor: | Muhammad Farooq Rai, Vicki Rosen, Robert H. Brophy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030203 arthritis & rheumatology
Knee function Knee biomechanics business.industry 0206 medical engineering 02 engineering and technology Osteoarthritis Meniscus (anatomy) Transcript level musculoskeletal system medicine.disease 020601 biomedical engineering Knee joint structure body regions 03 medical and health sciences Knee meniscus 0302 clinical medicine medicine.anatomical_structure medicine Orthopedics and Sports Medicine business Neuroscience |
| Zdroj: | Journal of Orthopaedic Research. 38:1895-1904 |
| ISSN: | 1554-527X 0736-0266 |
| DOI: | 10.1002/jor.24630 |
| Popis: | Injury to any individual structure in the knee interrupts the overall function of the joint and initiates a cascade of biological and biomechanical changes whose endpoint is often osteoarthritis (OA). The knee meniscus is an integral component of knee biomechanics and may also contribute to the biological homeostasis of the joint. Meniscus injury altering knee function is associated with a high risk of OA progression, and may also be involved in the initiation of OA. As the relationship between meniscus injury and OA is very complex; despite the availability of transcript level data on human meniscus injury and meniscus mediated OA, mechanistic studies are lacking, and available human data are difficult to validate in the absence of patient-matched noninjured control tissues. As similarities exist between human and mouse knee joint structure and function, investigators have begun to use cutting-edge genetic and genomic tools to examine the usefulness of the mouse as a model to study the intricate relationship between meniscus injury and OA. In this review, we use evidence from human meniscus research to identify critical barriers hampering our understanding of meniscus injury induced OA and discuss strategies to overcome these barriers, including those that can be examined in a mouse model of injury-mediated OA. |
| Databáze: | OpenAIRE |
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