| Popis: |
Publisher Summary This chapter focuses on arguing for new approaches and seeks to change how lipid oxidation analyses are viewed and used to attain more complete and accurate information. Lipid oxidation presents several distinctive challenges for analysis: (1) providing quantitative, reproducible analyses that accurately reflect oxidation chemistry; (2) tracking multiple pathways to avoid missing oxidation and to gain a more complete picture of the full extent and effects of oxidation; (3) obtaining maximum detailed information about specific products, their formation and degradation rates, and their potential transformations; (4) tracking the footprints of oxidation in co-oxidation products to avoid underestimating lipid oxidation and to assess the full range of oxidative deterioration in the system; (5) data mining: gleaning maximum information from large volumes of data; and (6) integrating multi-pathway data to develop a new understanding of lipid oxidation. The chapter considers theses challenges, presents more experimental detail in this area, and introduces more concepts and possibilities because these represent the directions readers need to move in the development of lipid oxidation assays. It also introduces the fundamental approaches of chemo metrics and proposes several ways in which they may apply to analyses of lipid oxidation. |
