Synthesis of composite biomaterials in the hydroxyapatite-calcite system

Autor:	M. A. Goldberg, Inna V. Fadeeva, S. M. Barinov, V. V. Smirnov, T. V. Shibaeva, L. I. Shvorneva
Rok vydání:	2010
Předmět:	Calcite Biocompatibility Chemistry Composite number chemistry.chemical_element General Chemistry Calcium Bone tissue Phosphate Resorption chemistry.chemical_compound medicine.anatomical_structure Phase composition medicine Biomedical engineering
Zdroj:	Doklady Chemistry. 432:151-154
ISSN:	1608-3113 0012-5008
DOI:	10.1134/s0012500810050095
Popis:	New medical engineering processes for repair of human bone tissue damaged upon diseases or injury are based on implanting porous scaffolds made of bio� compatible materials with cultivated osteoforming cells into the defect site [1–5]. With time, this struc� ture is replaced by bone tissue formed de novo. Apart from biocompatibility with the body, the requirements to the scaffold material include also time coherence between the resorption and the formation of a new bone tissue. Materials based on calcium phosphates, especially hydroxyapatite (HA), which is analogous in the chemical and phase composition to the mineral component of bone tissue, is best suited for this pur� pose. However, HA is the calcium phosphate most resistant to resorption. The resorption kinetics can be controlled by introducing a second, more soluble phase to the HA. To this end, composite materials in the HA–tricalcium phosphate system were developed [4, 5]; however, these materials still suffer from a num�
Databáze:	OpenAIRE
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