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Introduction: Dental caries are not due to a single organism, but to complex interactions among multiple microbes found in the oral cavity. Microbiome studies have identified multiple organisms associated with dental caries in both the saliva and dental plaque, but taxa identified vary largely by study. Our scoping review aims to create a comprehensive list of cariogenic and prohealth taxa found in saliva and dental plaque among healthy children and adults that compare caries-active and caries-free populations. Methods: We searched published studies querying the PUBMED and EMBASE databases using the following keywords: (plaque OR saliva) AND caries AND (next generation sequencing OR checkerboard OR 16s rRNA or qPCR). Studies were limited to human studies published in English between January 1, 2010 and June 24, 2020.Results: Our search strategy identified 298 identified articles. After applying the exclusion criteria, 22 articles were included (Figure 1, Table 1 and 2). Taxa associated with caries or health varied widely among the studies reviewed, with notable differences by age and biologic sample type. While no single taxa was associated with caries in all studies, Streptococcus mutans was significantly associated with caries in 12/24 studies (50%) and Fusobacterium periodonticum was significantly associated with prohealth in 4/24 studies (16.7%). Conclusion: No taxa in plaque and salivary microbiomes were consistently associated with caries or prohealth across all studies. This may be due to the inconsistency of timing of sample collection during the caries process, differing sequencing methods, lack of correction for multiple testing or possibly indicate that there are multiple ways that the oral microbiome can be cariogenic or prohealth. |
