Attachment of a styryl group to the 6-position of a protected penicillanic acid via cobaloxime-mediated radical alkyl-alkenyl cross coupling

Autor:	William D. Detlefsen, Bruce P. Branchard
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Styrene Coupling (electronics) chemistry.chemical_compound chemistry Group (periodic table) Drug Discovery Molecular Medicine Penicillanic Acid Molecular Biology Alkyl
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2289-2292
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00415-5
Popis:	Cobaloxime-catalyzed cross coupling of styrene with 6α-bromopenicillanic acid pivalolyl-oxymethyl ester (4) introduces a styryl group into the 6 position of the penicillanic acid nucleus. The method should be capable of introducing a variety of aryl-substituted alkenes into the 6 position. Such compounds may be useful as novel β-lactam antibiotics/β-lactamase inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a684a836274cc3f2b3313f5d811e3ba9 https://doi.org/10.1016/0960-894x(96)00415-5 Zobrazit plný text záznamu Full Text from ScienceDirect