Asymmetric Friedel-Crafts reaction mediated by new chiral auxiliaries derived from (1S)-(−)-β-pinene: Enantioselective synthesis of (−)-8-Norethyl, 1′-normethyl Etodolac

Autor:	Paulo R. R. Costa, Mário L. A. A. Vasconcellos, Lucio Mendes Cabral, Karla G. Alencar, Luciana L. Schmidt
Rok vydání:	1997
Předmět:	Pinene Organic Chemistry Enantioselective synthesis Alkylation Biochemistry chemistry.chemical_compound Hydrolysis chemistry Drug Discovery Tryptophol medicine Organic chemistry Etodolac Friedel–Crafts reaction medicine.drug
Zdroj:	Tetrahedron Letters. 38:7021-7024
ISSN:	0040-4039
Popis:	(−)-8-Norethyl, 1′-normethyl Etodolac (−)-7 was synthesized in ee up to 95% from a Friedel-Crafts alkylation reaction between tryptophol 4 and the chiral β-ketobutyrate 5h , followed by hydrolysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a683698ede6d5da77ba7ba4b2a265cd6 https://doi.org/10.1016/s0040-4039(97)01658-4 Zobrazit plný text záznamu Full Text from ScienceDirect