Advances in amphiphilic hyperbranched copolymers with an aliphatic hyperbranched 2,2-bis(methylol)propionic acid-based polyester core

Autor:	Guofei Dai, Yu Dai, Xiaojin Zhang
Rok vydání:	2020
Předmět:	Polymers and Plastics Chemistry Organic Chemistry Nanoparticle Bioengineering Biochemistry Polyester Drug delivery Amphiphile Copolymer Organic chemistry Hybrid material Drug carrier Macromolecule
Zdroj:	Polymer Chemistry. 11:964-973
ISSN:	1759-9962 1759-9954
DOI:	10.1039/c9py01608b
Popis:	Because of a highly branched architecture and a large number of functional groups on the molecular periphery, biodegradable and commercially available aliphatic hyperbranched 2,2-bis(methylol)propionic acid-based polyesters have a wide variety of applications in coatings, additives, tougheners, hybrid materials, drug carriers, and macromolecular building blocks. One of the most interesting applications is the synthesis of amphiphilic hyperbranched copolymers with an aliphatic hyperbranched 2,2-bis(methylol)propionic acid-based polyester core. In this Review, developments in the synthesis of amphiphilic hyperbranched copolymers are presented in terms of Boltorn™ Hx (x = 20, 30, 40), a series of commercial aliphatic hyperbranched polyesters. Applications include drug delivery, transfection, bio-imaging, and nanoparticle preparation. Challenges and perspectives for future developments are discussed as well.
Databáze:	OpenAIRE
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