| Autor: |
Katarzyna Drabko, Dorota Dlubek, Monika Dzierzak-Mietla, Miroslaw Markiewicz, Slawomira Kyrcz-Krzemien, Anna Gronkowska, Jerzy Kowalczyk, Jolanta Goździk, Andrzej Lange, W.W. Jędrzejczak, Jacek Nowak, Sylwia Mizia, Emilia Jaskula, K. Warzocha, Andrzej Hellmann |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Tissue Antigens. 82:387-396 |
| ISSN: |
0001-2815 |
| DOI: |
10.1111/tan.12255 |
| Popis: |
Four hundred and ninety-five patients (390 and 105 grafted from unrelated and sibling (SIB) donors, respectively) and their donors were analyzed for the impact of interleukin-10 (IL-10) promoter genotype [rs18000896 (-1082 G/A), rs18000871 (-819 C/T) and rs18000872 (-592 C/A)] on the outcome of hematopoietic stem cell transplantation (HSCT). Patients having ACC haplotype were at a lower risk of acute graft versus host disease (aGvHD, grade > I) if transplanted from human leukocyte antigen (HLA) well-matched (10/10) unrelated donors (20/135 vs 39/117, P I. ACC carriers had higher proportions of FoxP3+ lymphocytes gated in CD4+ lymphocytes as compared with patients with other IL-10 haplotypes. It was seen at the time of hematological recovery (mean ± SEM: 3.80 ± 0.91% vs 2.06 ± 0.98%, P = 0.012) and 2 weeks later (5.32 ± 0.87% vs 2.50 ± 0.83%, P = 0.013); -592 C/A polymorphism was separately analyzed and it was found that AA homozygotes tended to have a higher incidence of aGvHD (8/15 vs 116/456, P = 0.034) and low proportions of FoxP3 CD4+ lymphocytes in blood (0.43 ± 0.22% vs 4.32 ± 0.71%, P = 0.051) measured 2 weeks after hematological recovery. Functional IL-10 polymorphism associated features influenced the risk of aGvHD with a positive effect of ACC on the pool of Treg in blood. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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