Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors
| Autor: | François Mailliet, Hongshi Qi, Thérèse M. Jay, Per Svenningsson, Michael Spedding, Cyril Rocher |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Antiglucocorticoid Hippocampus Long-term potentiation Mifepristone Biology Blockade chemistry.chemical_compound Endocrinology Glucocorticoid receptor Developmental Neuroscience Neurology chemistry Internal medicine medicine Chronic stress Prefrontal cortex Neuroscience medicine.drug |
| Zdroj: | Experimental Neurology. 211:593-596 |
| ISSN: | 0014-4886 |
| DOI: | 10.1016/j.expneurol.2008.02.030 |
| Popis: | We previously reported that exposure to acute and chronic stress impairs long-term potentiation (LTP) in the hippocampal-prefrontal cortex pathway and showed evidence for a fundamental role of the prefrontal cortex in maladaptive responses to stress. The goal of the current studies was to examine whether blockade of glucocorticosteroid receptors (GR), by mifepristone (a Type II glucocorticoid receptor antagonist), just after exposure to acute stress could prevent stress-induced impairment of prefrontal LTP. We further examine the effects of mifepristone on mitogen-activated protein/ERK kinase (MEK) signaling pathway in the prefrontal cortex. The data show that an acute injection of mifepristone after stress restored the stress-induced blockade of prefrontal LTP and reduction of phospho-Ser217/221-MEK. These findings have significance for the treatment of memory deficits in hypercortisolemic states, such as stress and depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect