A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
| Autor: | Robert S. Garofalo, Meng-Ping Tu, D. Epstein, Marc Tatar, C.-M. Yin, A. Kopelman |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Multidisciplinary biology media_common.quotation_subject fungi Mutant Longevity biology.organism_classification Insulin receptor Endocrinology Drosophilidae Internal medicine Genetics of aging medicine biology.protein Drosophila melanogaster Receptor Drosophila Protein media_common |
| Zdroj: | Science. 292:107-110 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1057987 |
| Popis: | The Drosophila melanogaster gene insulin-like receptor ( InR ) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2 , a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR , which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue. |
| Databáze: | OpenAIRE |
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