Variation in biological embedding of stress among Syrian refugee children
| Autor: | Black, Candace, Smeeth, Demelza, McEwen, Fiona, Pluess, Michael |
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| Rok vydání: | 2022 |
| Předmět: |
Statistics and Probability
Telomere length Statistical Models Mental and Social Health Biological Psychology Puberty Social and Behavioral Sciences FOS: Sociology FOS: Psychology qPCR Sociology Pubertal development aTL Developmental Psychology Differential susceptibility Physical Sciences and Mathematics Medicine and Health Sciences Demography Population and Ecology Syrian refugees Psychology Environmental sensitivity Psychiatric and Mental Health Mental health Early life adversity Telomere Research Network |
| DOI: | 10.17605/osf.io/kr8dx |
| Popis: | This study investigates variation in biological embedding of stress among Syrian refugee children living in tented settlements in the Beqaa region of Lebanon. The data are drawn from the Biological Pathways of Risk and Resilience in Syrian Refugee Children (BIOPATH) funded by the Eunice Kennedy Shriver National Institute of Child Health & Human Development (R01HD083387). Research activities are supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 896988 and the Telomere Research Network (NIH U24 AG066528-03, PI: Stacy Drury). Saliva samples from 1,368 Syrian refugee children collected at Wave 1 will undergo telomere length assessment by qPCR resulting in measures of absolute telomere length, average telomere length, and T/S ratio. Telomere length will be evaluated in a moderated mediation model where telomere length mediates relations between war exposure and mental health outcomes (depression and PTSD symptoms), and environmental sensitivity moderates the relationship between war exposure and telomere length. We will also investigate associations between telomere length and pubertal development in boys and girls separately. Specifically, we will investigate if telomere length mediates the relations between war exposure and pubertal development. |
| Databáze: | OpenAIRE |
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