PREVENTION AND REVERSAL DESPITE HYPERGLYCEMIA OF GLYCOGEN INFILTRATION ('HYDROPIC DEGENERATION') IN THE PANCREAS IN ALLOXAN DIABETES IN THE RABBIT1

Autor:	G. Lyman Duff, W. E. Toreson
Rok vydání:	1951
Předmět:	medicine.medical_specialty Glycogen Pancreatic islets Biology medicine.disease Hydropic degeneration Tissue Degeneration Serous fluid chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Diabetes mellitus medicine Pancreas Infiltration (medical)
Zdroj:	Endocrinology. 48:298-312
ISSN:	1945-7170 0013-7227
Popis:	IN so-called “hydropic degeneration” of the pancreatic islets and ductular epithelium in experimental and human diabetes mellitus, glycogen can be demonstrated readily in the vacuolated cells by common histological techniques (Toreson, 1950). The characteristic vacuolar appearance of swollen pancreatic cells affected by “hydropic degeneration” is attributable to artefactual removal of intracytoplasmic accumulations of gtycogen rather than of excessive quantities of water (Weichselbaum and Stangl, 1902; Allen, 1913; Homans, 1915; and others) or of serous fluid (Ogilvie, 1949). This pancreatic lesion would be designated more precisely and distinctively by the term glycogen infiltration and we propose to use the term because we believe that careful re-examination of the various materials of previous authors would show the presence of glycogen in “hydropic” pancreatic cells in each instance. Glycogen infiltration of the islets of Langerhans is the sole histopathological feature common to all forms of permanen...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a665b028f61ccb410d7971b7546cb34b https://doi.org/10.1210/endo-48-3-298 Zobrazit plný text záznamu