Flavonoid glycosides and potential antivirus activity of isolated compounds from the leaves of Eucalyptus citriodora

Autor:	Zhong-Liu Zhou, Ke-Cheng Chen, Wen-Qing Yin, Zi-Ying Guo, San-qing Lin, Dan-Ying Huang, Cui-Liu Zhou, Lian-Mei Li, Xiao-Peng Zou
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Chromatography Flavonoid glycosides Chemistry Stereochemistry Organic Chemistry Extraction (chemistry) Flavonoid Glycoside General Biochemistry Genetics and Molecular Biology Solvent Column chromatography Eucalyptus citriodora IC50
Zdroj:	Journal of the Korean Society for Applied Biological Chemistry. 57:813-817
ISSN:	2234-344X 1738-2203
DOI:	10.1007/s13765-014-4264-0
Popis:	The extraction and solvent partition of the leaves of Eucalyptus citriodora, and repeated column chromatography for n-BuOH fraction yielded a new flavonoid glycoside, citrioside C (1), along with three known flavonoid glycosides (2–4). The latter were identified with kaempferol-3-O-β-d-glucopyranosyl (12)-α-l-rhamnoside (2), kaempferol-3-O-α-l-rhamnoside (3), and quercetin-3-O-α-l-rhamnoside (4). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. All constitutents were isolated for the first time from the leaves of Eucalyptus citriodora. The potential antivirus activity of all the isolated compounds was evaluated. Compound 4 showed potent antiviral activity against respiratory syncytial virus with 50% inhibition concentration (IC50) value of 1.9 μg/mL and selective index value of 9.8.
Databáze:	OpenAIRE
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