Quantitative analysis of chiral compounds from unresolved peaks in capillary electrophoresis using multivariate calibration with experimental design and artificial neural networks
| Autor: | Vlastimil Dohnal, Marta Farková, Josef Havel, Hua Li |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
Chromatography Artificial neural network 010405 organic chemistry Chemistry 010401 analytical chemistry Organic Chemistry Multivariate calibration 01 natural sciences Method development Catalysis 0104 chemical sciences Analytical Chemistry Capillary electrophoresis Drug Discovery Quantitative analysis (chemistry) Spectroscopy |
| Zdroj: | Chirality. 14:509-518 |
| ISSN: | 0899-0042 |
| DOI: | 10.1002/chir.10108 |
| Popis: | Quantitation of optical isomers can be achieved even from incompletely resolved peaks with a multivariate calibration applying a combination of experimental design and artificial neural networks (ANN). Using the proposed approach, method development can be more efficient and analysis time shortened while quantitation of optical isomers with acceptable precision (+-1-3%) can be achieved. |
| Databáze: | OpenAIRE |
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