Synthesis of antitumor 3,4,6,7-tetrahydro-2H-pyrimido[1,6-c]quinazolin-2-imine derivatives via reductive dearomatization-initiated intramolecular cyclization
| Autor: | Mingping Wang, Wei Tian, Yang Chen, Ju Zhu, Xiaotian Zhou, Feifei Ba, Yunlong Song, Chao Yang, Zhou Feng, Canhui Zheng, Shunmin Guo, Wei Li, Yu Liu, Youjun Zhou, Hao Guo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Imine Intramolecular cyclization 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Drug Discovery Human cancer |
| Zdroj: | Tetrahedron. 72:3185-3192 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2016.04.036 |
| Popis: | In light of the importance of N-fused heterocycles in pharmaceuticals, there is continuing interest in research on N-fused heterocycles and their preparation. A new and efficient reductive dearomatization-initiated intramolecular cyclization reaction with a broad scope has been developed, affording 3,4,6,7-tetrahydro-2H-pyrimido[1,6-c]quinazolin-2-imine derivatives. Notably, this type of compound showed good inhibitory activity against specific kinases and human cancer cell lines. These results might mean a new molecular scaffold for the development of new antitumor agents. |
| Databáze: | OpenAIRE |
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