Synthesis and structural characterization of N,N',N',N''-tetrasubstituted cyclams

Autor:	Rui F. Munhá, Ana M. Martins, Luis G. Alves
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Carbamic acid Aqueous solution Chemistry Decarboxylation Bromide Organic Chemistry Cyclam medicine Chloride Medicinal chemistry medicine.drug
Zdroj:	Chemistry of Heterocyclic Compounds. 57:871-874
ISSN:	1573-8353 0009-3122
Popis:	Tetrasubstituted cyclams of formulae (3,5-Me2C6H3CH2)4Cyclam and (4-MeC6H4SO2)4Cyclam were synthesized by reaction of cyclam with 4 equivalents of 3,5-dimethylbenzyl bromide and p-toluenesulfonyl chloride, respectively. Cyclam reacted with CO2 at atmospheric pressure to give (HOOC)4Cyclam, which displays four carbamic acid moieties. This reaction is reversible, and in aqueous solution a decarboxylation process takes place with formation of cyclam and release of CO2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a65d08082857c1d6ad80ffb4dfb7246a https://doi.org/10.1007/s10593-021-02994-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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