Pharmacogenomic agreement between two cancer cell line data sets

Autor: Elena J. Edelman, Francesco Iorio, Frank Stegmeier, Gregory V. Kryukov, Mahmoud Ghandi, Michael R. Stratton, Robert Schlegel, Iulian Pruteanu-Malinici, Kavitha Venkatesan, Ultan McDermott, William R. Sellers, Michael P. Menden, Markus Riester, Cyril H. Benes, Michael B. Morrissey, Arnaud Amzallag, Dmitriy Sonkin, Audrey Kauffmann, Mathew J. Garnett, Sridhar Ramaswamy, Joseph Lehar, Giordano Caponigro, Daniel A. Haber, Levi A. Garraway, Manway Liu, Jordi Barretina, Julio Saez-Rodriguez, Nicolas Stransky
Rok vydání: 2015
Předmět:
Zdroj: Nature. 528:84-87
ISSN: 1476-4687
0028-0836
DOI: 10.1038/nature15736
Popis: Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.
Databáze: OpenAIRE
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