An Observational Study of Intravenous Granisetron Vs Oral Gabapentin in Preventing Postoperative Nausea and Vomiting after Middle Ear Surgery

Autor:	Malini Mehta, Akshata Thakurdesai, Sujay Thakkar
Rok vydání:	2021
Předmět:	Gabapentin Nausea business.industry medicine.drug_class Health Toxicology and Mutagenesis Toxicology Granisetron Pathology and Forensic Medicine Anesthesia medicine Vomiting Midazolam Antiemetic medicine.symptom business Law Glycopyrrolate Postoperative nausea and vomiting medicine.drug
Zdroj:	Indian Journal of Forensic Medicine & Toxicology.
ISSN:	0973-9130 0973-9122
DOI:	10.37506/ijfmt.v15i3.15334
Popis:	Background- Postoperative nausea and vomiting (PONV) is one of the most unpleasant complications after middle ear surgery. Several studies have demonstrated use of gabapentin as antiemetic. This study aims at comparison of intravenous granisetron vs oral gabapentin in preventing PONV. Methods - 64 patients of ASA I or II between the ages of 18 and 65 years were divided equally into two groups. Patients in group I received 3mg granisetron iv 2 minutes and patients in group II received 300 mg gabapentin orally 1 hour prior to surgery. Patients were premedicated with inj. glycopyrrolate and inj. midazolam. Anaesthesia was induced, maintained and reversed in usual manner. Haemodynamic changes and number of episodes of nausea and vomiting were recorded upto 24 hours postoperatively. No statistically significant difference was observed in both the groups at 0 and 1 hour in preventing PONV (p
Databáze:	OpenAIRE
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