| Autor: |
Helen Y. Fung, Matthew Teryek, Alexander D. Lemenze, Tessa Bergsbaken |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Science Immunology. 7 |
| ISSN: |
2470-9468 |
| DOI: |
10.1126/sciimmunol.abl9925 |
| Popis: |
Tissue-resident memory T (T RM ) cells remain poised in the tissue and mediate robust protection from secondary infection. T RM cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of these T RM subsets to secondary infection remain poorly defined. To address the plasticity of intestinal T RM subsets and their role in local and systemic immunity, we generated mice to fate map intestinal CD103 + T RM cells and track their location and function during secondary infection with Yersinia pseudotuberculosis . We found that CD103 + T RM cells remained lodged in the tissue and were poorly reactivated during secondary challenge. CD103 − T RM cells were the primary responders to secondary infection and expanded within the tissue, with limited contribution from circulating memory T cells. The transcriptional profile of CD103 − T RM cells demonstrated maintenance of a gene signature similar to circulating T cells along with increased cytokine production and migratory potential. CD103 − T RM cells also expressed genes associated with T cell receptor (TCR) activation and displayed enhanced TCR-mediated reactivation both in vitro and in vivo compared with their CD103 + counterparts. These studies reveal the limited recall potential of CD103 + T RM subsets and the role of CD103 − T RM cells as central memory–like T cells within peripheral tissues. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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