| Autor: |
Alejandro Peñín-Franch, José A García-Vidal, Pablo Pelegrín, Fermín Valera-Garrido, Francesc Medina-Mirapeix, Ana I. Gomez, Francisco Minaya-Muñoz, Pilar Escolar-Reina, Carlos Martinez |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.09.20.461048 |
| Popis: |
The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathies lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing, complicating their clinical management. Percutaneous needle electrolysis consist in the application of a galvanic current and is emerging as a novel treatment for tendinopathies. Here we found that galvanic current activates the NLRP3 inflammasome and the induction of an inflammatory response promoting a collagen-mediated regeneration of the tendon. This study establish the molecular mechanism of percutaneous electrolysis for the treatment of chronic lesions and the beneficial effects of an induced inflammasome-related response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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