URINARY EXCRETION OF CITRIC ACID CYCLE METABOLITES IN PREMATURE NEWBORN INFANTS WITH AND WITHOUT A RESPIRATORY DISTRESS SYNDROME
| Autor: | P. Y. K. Wu, W. Oh, E. Polar, J. Metcoff |
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| Rok vydání: | 1965 |
| Předmět: | |
| Zdroj: | Pediatrics. 36:856-860 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.36.6.856 |
| Popis: | The excretion of CAC acids in the urine of 6 "normal" premature infants was measured during the first 24 hours of life and for a 12-hour period during the subsequent 48-hour period of life. Similar measurements were obtained in 10 premature infants with a respiratory distress syndrome (RDS). The CAC acids were quantified by gradient elution silicic acid column chromatography. Quantifiable acids included a pyruvate adjacent ("X") fraction, and pyruvic, lactic, citric, α-ketoglutaric, succinic, fumaric, malic, and acetic acids. Some of the urines did not contain all of the acids. Fumaric, malic, and succinic acids were encountered less frequently and the sample limitation precluded comparative analysis either with increasing neonatal age or between groups of premature infants without or with a RDS. Of the acids recovered in sufficient quantity to merit comparison, a significant increase in excretion of pyruvic and citric acids was observed during the 48-72 hour period in both groups of infants. The increment of citric acid excretion was greater (p < 0.02) in the infants without a RDS. The infants with RDS tended to excrete more pyruvic-like, lactic, malic, and acetic acids than did non-distressed subjects. ix-ketoglutaric acid increased as perinatal acidosis diminished. There were too few observations to lend statistical credence to these latter observations, which require further study. The intrinsic renal mechanism responsible for excretion of the CAC acids may be relevant to renal metabolism, which determines renal functional homeostasis in the neonatal period. |
| Databáze: | OpenAIRE |
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