Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor
Autor: | I. V. Vereshchaka, A. V. Maznychenko, Alexander I. Kostyukov, Olga L. Ocheretna, Volodymyr O. Maisky, Olena P. Mankivska, O. V. Vlasenko, Olexandr V. Dovgan, Tomasz Tomiak |
---|---|
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Sympathetic nervous system Achilles tendon Chemistry General Neuroscience Intermediolateral nucleus Long-term potentiation General Medicine musculoskeletal system Spinal cord Tendon Nitric oxide 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Endocrinology Internal medicine medicine Nucleus 030217 neurology & neurosurgery |
Zdroj: | Acta Neurobiologiae Experimentalis. 78:82-91 |
ISSN: | 1689-0035 0065-1400 |
DOI: | 10.21307/ane-2018-009 |
Popis: | We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achilles tendon vibration, after intramuscular (m. triceps surae) administration of 7‑nitroindazole (7‑NI) or L‑arginine (LA). The spindle afferent response to vibratory stimuli induced a distinct bilateral increase in the activation of c‑Fos immunoreactivity in the spinal neurons in three groups of rats (tendon‑vibrated, tendon‑vibrated + 7‑NI and tendon‑vibrated + LA). The T5/T13 segments in tendon‑vibrated +7‑NI animals showed the highest increase of Fos‑immunoreactive neurons. This increase was two times higher than that in tendon only‑vibrated control rats and endon‑vibrated + LA animals. The highest mean number of labelled neurons were observed in the IML nucleus and in layers 4 and 7 of the T5-L3 segments in tendon‑vibrated and tendon‑vibrated + 7‑NI animals, and in the IML nucleus and layer 4 in tendon‑vibrated + LA rats. The highest mean number of activated neurons was found ipsilaterally in the IML nucleus of the T5/T13 segment. These results indicate that decreased nitric oxide release after injection of 7‑NI was accompanied by a potentiation of the early c‑fos gene expression induced by muscle proprioceptive activity within the thoracolumbar region of the rat spinal cord. Thus, enhanced c‑Fos immunoreactivity in the IML nucleus indicated that the sympathetic nervous system can exert a direct influence on the muscle spindles. |
Databáze: | OpenAIRE |
Externí odkaz: |
načítá se...