Metabolic Profiles in a Transgender Adolescent Population Receiving Steroid Hormone Therapy: A Pilot Study
| Autor: | Veronica Gomez-Lobo, Leah Orta, Rachel K. Casey, Lauren Damle, Gylynthia Trotman, Liz Oler |
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| Rok vydání: | 2014 |
| Předmět: |
Biologic marker
medicine.medical_specialty education.field_of_study biology medicine.drug_class business.industry medicine.medical_treatment Population Obstetrics and Gynecology General Medicine Steroid hormone Endocrinology Sex hormone-binding globulin Estrogen Sex steroid Internal medicine Pediatrics Perinatology and Child Health medicine biology.protein education business Body mass index Testosterone |
| Zdroj: | Journal of Pediatric and Adolescent Gynecology. 27:e38 |
| ISSN: | 1083-3188 |
| DOI: | 10.1016/j.jpag.2014.01.037 |
| Popis: | Background: Although data in the adult transgendered population has suggested the use of sex steroids hormones could also alter metabolic parameters this effect has not been studied in the adolescent population. This study aims to identify patterns or changes in the metabolic profiles of the female-to-male (FTM) and male-to-female (MTF) adolescent transgendered patients undergoing sex hormone therapy. Methods: We conducted a retrospective pilot study examining the database of patients identified as having gender identity disorder and started on sex steroid hormone for transitioning during a 5 year period and had at least 4 follow-up lab values. Patients were stratified into two treatment groups: MTF and FTM. We reviewed baseline values and subsequent trends in body mass index (BMI) in addition to biologic markers including cholesterol levels (total cholesterol, LDL, HDL, and triglyceride), testosterone level, estradiol level, liver function tests, prolactin level, HgbA1c, CBC and electrolytes. The Wilcoxon rank sum test was used to examine differences between the two groups. Results: A total of 8 FTM and 6 MTF patients were identified. In the FTM group on testosterone, there was a significant increase in the hematocrit levels (p1⁄40.0473). In addition, although not significant there was a trend toward increasing total cholesterol, LDL and BMI with a decrease in HDL levels. In the MTF group on estrogen, although the values did not reach significance there was a trend toward increasing triglycerides, HDL and prolactin levels. In comparing the metabolic profile changes between the MTF and FTM groups the MTF group were more likely to have a lower BMI (p |
| Databáze: | OpenAIRE |
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