APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity

Autor:	John M. Delaney, Xing-Zhong Xia, Nessa Hawkins, Meena Ramakrishnan, Gang Yu, Masayo Kornuc, Susan McCabe, Tom Boone, Lars Eyde Theill, Wan-rong Qiu, Giorgio Senaldi, Ildiko Sarosi, Jane Guo, Marina Stolina, Hailing Hsu, Michael J. Kelley, William J. Boyle
Rok vydání:	2000
Předmět:	T cell B-Cell Maturation Antigen Transmembrane activator and CAML interactor Immunology Biology Cell biology medicine.anatomical_structure Humoral immunity medicine biology.protein Immunology and Allergy B-cell activating factor BAFF receptor Receptor Keyhole limpet hemocyanin
Zdroj:	Nature Immunology. 1:252-256
ISSN:	1529-2916 1529-2908
Popis:	We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-1 (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-1 signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL–TALL-1 and BCMA-TACI form a two ligands–two receptors pathway involved in stimulation of B and T cell function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a63127a99d03ff6ce1caf68871d06630 https://doi.org/10.1038/79802 Zobrazit plný text záznamu Plný text ve formátu PDF