Digitonin-cholesterol complex formation: Effects of varying the length of the side-chain

Autor:	Ushio Sankawa, Shigekazu Takagi, Toshiyuki Akiyama, Hideaki Otsuka
Rok vydání:	1982
Předmět:	chemistry.chemical_classification Cholesterol Stereochemistry Complex formation Saponin General Chemistry General Medicine Aqueous ethanol chemistry.chemical_compound Digitonin chemistry Drug Discovery Biophysics Side chain
Zdroj:	Chemical and Pharmaceutical Bulletin. 30:3485-3492
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.30.3485
Popis:	A method was designed to study complex formation between saponin and cholesterol in aqueous ethanol, and was applied, with some modifications, to examine the ability of cholesterol analogues bearing various lengths of side-chain to form complexes (digitonides) with digitonin. The results indicated that all the analogues were capable of forming digitonides regardless of the length of the side-chain, but the effectiveness of digitonide formation increased as the length of the side-chain increased. A plausible structural model is proposed for the digitonide in order to interpret these results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a62f09b248aadf99acfd508d67385ee4 https://doi.org/10.1248/cpb.30.3485 Zobrazit plný text záznamu