Senescent Alterations in the Retina and Retinal Pigment Epithelium: Evidence for Mechanisms Based on Nutritional Studies
| Autor: | Martin L. Katz, W. Gerald RobisonJr. |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
education.field_of_study
Retina Retinal pigment epithelium genetic structures business.industry Incidence (epidemiology) Population Physiology Retinal Macular degeneration medicine.disease eye diseases Photoreceptor cell chemistry.chemical_compound medicine.anatomical_structure chemistry Etiology Medicine sense organs business education |
| Zdroj: | The Effects of Aging and Environment on Vision ISBN: 9781461366744 |
| Popis: | Age-related diseases of the retina are among the most prevalent causes of serious visual impairment in developed countries. Those retinal diseases affecting the macular region have the most pronounced effects on visual capacity. Data from an epidemiological study conducted by the National Center for Health Statistics indicate that the incidence of age-related macular degeneration (AMD) in the United States is approximately 85 per 1,000 of the population 65 to 74 years of age (11). In the Framingham Eye Study, the incidence of AMD was found to be 110 per 1,000 of population in the same age group, and rose to 280 per 1,000 in those 75 to 85 years of age (34). At present, our understanding of the etiology of AMD is extremely limited, but it is likely that age-related diseases of the macula develop as the result of underlying senescent alterations in the retina and associated tissues. If we are to retard or prevent the development of AMD, therefore, it will be necessary to identify primary senescent changes that may lead to the development of macular degeneration. |
| Databáze: | OpenAIRE |
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