Synthesis of (+)-trixagol and its enantiomer, the terpenoid side chain of (−)-agelasine E

Autor:	Lise-Lotte Gundersen, Anne Kristin Bakkestuen
Rok vydání:	2003
Předmět:	Cyclohexanemethanol chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Side chain Agelasine Enantiomer Alkylation Biochemistry Terpenoid
Zdroj:	Tetrahedron. 59:115-121
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(02)01455-2
Popis:	The naturally occurring γ-cyclogeranylgeraniol called (+)-trixagol has been synthesised for the first time. Trixagol was readily available in five steps from ( S )-2,2-dimethyl-6-methylene-1-cyclohexanemethanol. The enantiomer of trixagol, which equates to the terpenoid side chain of the naturally occurring 7,9-dialkylpurinium salt (−)-agelasine E, was prepared from the ( R ) enantiomer of the cyclohexanemethanol. Both trixagol enantiomers were moderately active against Mycobacterium tuberculosis .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a624cc70d44b442d3a4a6f8f22fbad06 https://doi.org/10.1016/s0040-4020(02)01455-2 Zobrazit plný text záznamu Full Text from ScienceDirect