Positron Emission Tomography and Boron Neutron Capture Therapy System to the Patient with Malignant Brain Tumor
| Autor: | Yutaka Mishima, Masao Takagaki, Yoshifumi Oda, K. Ono, Tooru Kobayashi, Eiji Yoshino, Satoshi Ueda, Yoshio Ohmori, Yoshio Imahori, Tatsuo Ido |
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| Rok vydání: | 1996 |
| Předmět: |
endocrine system
medicine.diagnostic_test Side effect urogenital system Chemistry business.industry chemistry.chemical_element medicine.disease Neutron capture Positron Positron emission tomography Glioma medicine Brain positron emission tomography Nuclear medicine business Boron hormones hormone substitutes and hormone antagonists Gamma counter |
| Zdroj: | Cancer Neutron Capture Therapy ISBN: 9781475795691 |
| DOI: | 10.1007/978-1-4757-9567-7_116 |
| Popis: | We have conjugated a positron tracer F-18 to [10B]boronophenylalanine (10B-BPA) to synthesize [18F]fluoroboronophenylalanine (18F-10B-DL-BPA or 18F-10B-L-BPA), and analyzed 1013-BPA metabolism on 27 cases of the various brain tumors by positron emission tomography (PET). These PET data revealed that 18F-10B-BPA using the DL-form was actively incorporated to the malignant tumor cells, showing high B-10 concentration and T/N ratio, which was suggested of the sufficient effectiveness of boron neutron capture therapy (BNCT) on the malignant brain tumor. The experimental studies were undertaken with rat glioma model which showed that BNCT using 10B-L-BPA brought the good antitumor effect on rat glioma and no side effect on normal brain. Under this PET-BNCT system, the patient with malignant brain tumor was treated. |
| Databáze: | OpenAIRE |
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