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Purpose: Corneal staining associated with contact lens wear and multipurpose solutions (MPS) may indicate ocular surface toxicity. However, corneal staining varies with the time of evaluation. These studies examined corneal staining over time of three MPSs with balafilcon A lenses. Method: Three MPSs were evaluated in two studies: Solution A (COMPLETE® RevitaLens Multi-PurposeDisinfecting Solution [MPDS], Abbott Medical Optics Inc.); Solution B (Opti-Free® RepleniSH® MPDS, Alcon, Inc.] and Solution C (BiotrueTM MPS, Bausch & Lomb Incorporated). These studies were double-masked, contralateral eye, with 29 to 30 subjects. Subjects were randomized to wear lenses soaked in different MPSs in each eye. After baseline evaluations, follow-up visits occurred after one, two, four and six+ hours (end-of-day) of lens wear. Corneal staining was graded on severity and extent by a five-point scale, while comfort was assessed by a 10-point scale. Results: Significant differences in corneal staining extent were found between Solutions A and B at two hours (p=0.037) and Solutions A and C at every follow-up time point (p |
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