Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism
| Autor: | Jean-Michel Warnet, S. Ellouk-Achard, M. Thevenin, C. Martin, H. Dutertre-Catella, C. Pham-Huy, J. R. Claude, V. Levresse |
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| Rok vydání: | 1995 |
| Předmět: |
Calcium metabolism
digestive oral and skin physiology Glutathione reductase chemistry.chemical_element macromolecular substances Glutathione Calcium Pharmacology medicine.disease_cause Acetaminophen Toxicology chemistry.chemical_compound chemistry medicine sense organs skin and connective tissue diseases Ex vivo Oxidative stress Homeostasis medicine.drug |
| Zdroj: | Archives of Toxicology ISBN: 9783642794537 |
| DOI: | 10.1007/978-3-642-79451-3_18 |
| Popis: | The hepatotoxicity of acetaminophen (APAP) seems to be linked to several biochemical perturbations such as glutathione depletion, oxidative stress, Ca2+ homeostasis disturbances and/or changes in energy metabolism. |
| Databáze: | OpenAIRE |
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