Guided optimization of a crystallization-induced diastereomer transformation to access a key navoximod intermediate

Autor: Andrew J. Kukor, Frédéric St-Jean, Andreas Stumpf, Thomas C. Malig, Katarzyna A. Piechowicz, Kenji Kurita, Jason E. Hein
Rok vydání: 2023
Předmět:
Zdroj: Reaction Chemistry & Engineering.
ISSN: 2058-9883
DOI: 10.1039/d3re00077j
Popis: The crystallization-induced diastereomer transformation of a precursor to navoximod was investigated using online HPLC and optimized with inline racemization.
Databáze: OpenAIRE