Non-peptide α v β 3 antagonists. Part 7: 3-Substituted tetrahydro- [1,8] naphthyridine derivatives

Autor:	Michael J. Breslin, Sevgi B. Rodan, Gideon A. Rodan, Chih-Tai Leu, George D. Hartman, John H. Hutchinson, Le T. Duong, Hunt Cecilia, Mark E. Duggan, Paul J. Coleman, Jiabing Wang
Rok vydání:	2004
Předmět:	Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Non peptide In vitro In vivo Drug Discovery Molecular Medicine Potency Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 14:1049-1052
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2003.11.036
Popis:	A series of 3-substituted tetrahydro-[1,8]naphthyridine containing α v β 3 antagonists was prepared. A comparison of their in vitro IC 50 values to the electron properties of the 3-substituents revealed a good linear Hammett correlation (ρ=−1.96, R 2 =0.959). Electron-withdrawing groups at the 3-position of the tetrahydro-[1,8]naphthyridine decreased potency while electron-donating groups enhanced potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a606a99dad25be7e75818391f5a9866e https://doi.org/10.1016/j.bmcl.2003.11.036 Zobrazit plný text záznamu Full Text from ScienceDirect