Prevalence and Identification of Type 1 Diabetes in Chinese Adults with Newly-Diagnosed Diabetes

Autor: Xia Li, Xiaohan Tang, Xiang Yan, Houde Zhou, Gan Huang, Shuoming Luo, Xilin Yang, Xiaohong Niu, Jing Liu, Caifeng Yan, Huibiao Quan, Chao Zheng, Liyong Yang, Gebo Wen, Tao Yang, Hongwei Jiang, Meibiao Zhang, Jianping Wang, Heng Su, Zhiming Deng, Qiuxia Huang, Yi Zhang, Hui Sun, Zhaohui Mo, Qifu Li, Changqing Luo, Lixin Guo, Yuling He, Jian Kuang, Hui Fang, Ling He, Yu Liu, Zhongyan Shan, Qiuhe Ji, Linong Ji, Zhiguang Zhou, National Clinical Research Center f Group
Rok vydání: 2018
Předmět:
Zdroj: SSRN Electronic Journal.
ISSN: 1556-5068
DOI: 10.2139/ssrn.3269603
Popis: Background: The incidence of type 1 diabetes mellitus (T1DM), especially in children, has rapidly increased in China. However, the prevalence of adult-onset classic T1DM and latent autoimmune diabetes of adults (LADA) remains unknown. Methods: A nationwide, multicenter survey of newly-diagnosed diabetes in adults aged ≥30 years was conducted from hospitals in 24 Chinese provincial administrative areas from April 2015 to October 2017. Classic T1DM, identified based on insulin-dependency, and standardized glutamic acid decarboxylase autoantibody testing, was used to differentiate LADA from patients with initially an undefined diabetes type. The age and sex distributions from a large national survey of diabetes in China conducted in 2010, were used to standardize the prevalence of T1DM and LADA. Findings: Among 17,349 adult patients, the prevalence of T1DM was 5·84% (5·14% in males and 6·16% in females), with 65% of these having LADA. The prevalence of classic T1DM decreased with increasing age (p 0·05). The prevalence of T1DM in overweight or obese patients was 3·4% and 2·4%, respectively, and LADA accounted for 75% and 80% of T1DM in these two groups. LADA's cumulative age distribution was much closer to type 2 diabetes mellitus (T2DM) than to that of classic T1DM. Interpretation: T1DM, especially LADA, was prevalent in newly-diagnosed adult-onset diabetes in China, which highlights the importance of identification of LADA in clinical practice in China. Funding Statement: The National Science and Technology Infrastructure Program and the National Key R&D Program of China. Declaration of Interests: The authors declare that they have no competing interests. Ethics Approval Statement: The ethics review committee/institutional review board of each of the participating hospitals approved the study protocol. Written informed consent was obtained from all the participants before data collection.
Databáze: OpenAIRE
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