Measuring Platelet Aggregation in Dialysis Patients With a Whole Blood Aggregometer by the Screen Filtration Pressure Method

Autor:	Takashi Kadowaki, Aki Hayashi, Yoshiyuki Honma, Kayo Waki, Shigeo Ikeda, Kazuhiro Nagatsuka, Sadayoshi Yoshinoya, Sadao Ikeda
Rok vydání:	2010
Předmět:	medicine.medical_specialty Platelet aggregation business.industry medicine.medical_treatment Urology Hematology Control subjects medicine.disease Dialysis patients Surgery Nephrology Diabetes mellitus medicine Platelet Hemodialysis business Whole blood
Zdroj:	Therapeutic Apheresis and Dialysis. 15:203-206
ISSN:	1744-9979
DOI:	10.1111/j.1744-9987.2010.00899.x
Popis:	A semi-automatic, whole-blood aggregometer based on the screen filtration pressure (SFP) method is now widely used clinically and in research, but has not been used with hemodialysis (HD) patients. We measured whole-blood platelet aggregation in HD patients by the SFP method. This retrospective cross-sectional study included 62 HD patients, of whom 47 were non-diabetic and 15 were diabetic; we also included a control group of healthy, non-uremic subjects. With the t-test, we examined differences in the platelet aggregation threshold index (PATI) in meaningful sub-groupings of the HD patients, depending on whether or not they had diabetes, and whether or not they had been given antiplatelet agents. Considering the non-diabetic HD patients first, their PATI values were significantly higher than those values in the control subjects (3.1 [1.0–5.2] vs. 1.8 [1.3–2.3] µM, P
Databáze:	OpenAIRE
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