Concise syntheses of (±)-protoemetinol and related alkaloids using radical cyclisation

Autor:	Matthew J. Palframan, Johnson Paul David, Andrew F. Parsons
Rok vydání:	2011
Předmět:	Protoemetinol chemistry.chemical_compound biology chemistry Alkaloid Organic Chemistry Drug Discovery Organic chemistry Alangium Tributyltin hydride Mitragyna biology.organism_classification Biochemistry
Zdroj:	Tetrahedron Letters. 52:1154-1156
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.01.007
Popis:	Both (±)-protoemetinol, its 3-epi-isomer and (±)-3-desmethyl protoemetinol have been prepared in five linear steps from a dihydroisoquinoline using a 6-exo-trig cyclisation of a vinyl radical in the key step. This novel and particularly short route has potential application in the synthesis of Alangium and Mitragyna alkaloids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a5fb96415e0b2d32cbbc92f59c5b9c35 https://doi.org/10.1016/j.tetlet.2011.01.007 Zobrazit plný text záznamu Full Text from ScienceDirect