Impact of Apo Lipoprotein E Gene Polymorphism on Hepatitis C Virus Disease Progression and Response to Direct Acting Antivirals in the Egyptian Population
| Autor: | Ahmed Elsadek Fakhr, Ayaat Mohamed Zedan, Fayrouz Othman Selim, Monkez M Yousif, Ghada Mohamed Samir |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Apolipoprotein E
education.field_of_study Hepatology Apolipoprotein B biology business.industry Hepatitis C virus Population medicine.disease_cause Virology Virus 03 medical and health sciences 0302 clinical medicine Infectious Diseases Genotype biology.protein Medicine lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology 030212 general & internal medicine Gene polymorphism business education Lipoprotein |
| Zdroj: | Hepatitis Monthly. 20 |
| ISSN: | 1735-3408 1735-143X |
| DOI: | 10.5812/hepatmon.101516 |
| Popis: | Background: Hepatitis C virus infection is a major health problem in Egypt. Apo lipoprotein E and lipid metabolism are closely associated with the life cycle of the virus and play an important role in facilitating this infection. Objectives: To identify the role of apolipoprotein E gene polymorphism on hepatitis C virus disease progression and response to direct-acting antivirals (DAAs). Methods: We included twenty patients with chronic hepatitis C virus infection (CHC) from those who failed to respond to DAAs treatment and 76 subjects from responders. Apo lipoprotein E genotypes were determined using PCR restriction enzyme fragment length polymorphism (RFLP). Results: Apolipoprotein genotype E3/E3 was prevalent in 75.9% of patients. The distribution for the rest of genotypes was 16.9%, 3.6%, 2.4% and 1.2 % for Apo E3/E4, E2/E3, E4/E4, and E2/E2 respectively. No statistically significant difference was found regarding any of the Apo E genotypes with liver cirrhosis or response to therapy. Conclusions: No significant impact for any Apo E genotypes on CHC disease severity or response to therapy with direct-acting antivirals was detected among Egyptian patients. |
| Databáze: | OpenAIRE |
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