Effect of Dihydropyridine Calcium Channel Blockers on the Plasma Digoxin Level
| Autor: | Kouziro Awano, Masanori Hayakawa, Hiroomi Nakamura, Hisashi Fukuzaki, Akira Shimizu, Mitsuyasu Terashima, Ryuichi Emoto, Tsutomu Kuroda, Yasuaki Hashimoto |
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| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Digoxin business.industry medicine.drug_class Calcium channel digestive oral and skin physiology Dihydropyridine Calcium channel blocker carbohydrates (lipids) Manidipine Nifedipine Nitrendipine polycyclic compounds Medicine Nisoldipine Pharmacology (medical) cardiovascular diseases business medicine.drug |
| Zdroj: | Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 27:665-671 |
| ISSN: | 1882-8272 0388-1601 |
| Popis: | The effects of four dihydropyridine calcium channel blockers (nifedipine, nisoldipine, nitrendipine and manidipine) on the plasma digoxin level were studied in patients and the effects of nitrendipine and nisoldipine were compared in beagle dogs . In the clinical study, the mean plasma concentration of digoxin was significantly higher during combined administration with nitrendipine than with the other calcium channel blockers. In addition, the digoxin level was decreased by about 50% at one month after changing the calcium channel blocker from nitrendipine to nisoldipine. In dogs, combined administration with nitrendipine resulted in a significantly higher plasma digoxin level after 2 and 4 hrs and a significantly larger mean area under the plasma concentration time curvecompared with administration without nitrendipine (p |
| Databáze: | OpenAIRE |
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